A Choline Transporter and Autoimmune Hearing Loss
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چکیده
Antibodies to neural antigens cause several neurological diseases, myasthenia gravis with its acetylcholine receptor antibodies being perhaps the best known. Autoimmune damage is also suspected as a cause of rapidly progressive hearing loss. In this issue, Nair et al. track down the antigen underlying hearing loss that is caused by an antibody (KHRI-3) generated against the guinea pig organ of Corti. They isolated and sequenced the inner ear supporting cell antigen as choline transporter-like protein 2 (CTL2). Supporting cells bound KHRI-3 and antiCTL2 with a punctate, “wine-glass” pattern. A similar pattern also can be seen in humans with autoimmune hearing loss. CTL2 is expressed in humans, although its function is not yet known. Because the antibody binds to carbohydrate moieties on the putative extracellular domain of CTL2, the authors speculate that the antibody blocks a possible transporter function.
منابع مشابه
Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss.
The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain insight into the mechanism of antibody-induced hearing loss, we used antibody immunoaffinity purification to isolate the IESCA, which was then sequenced by mass spectroscopy, revealing 10 guinea pig peptides identical to sequences in human ch...
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تاریخ انتشار 2004